Werner helicase interacting protein 1 contributes to G-quadruplex processing in human cells

Werner helicase interacting protein 1 contributes to G-quadruplex processing in human cells

Abstract Genome replication is frequently impeded by highly stable DNA secondary structures, including G-quadruplex (G4) DNA, that can hinder the progression of the replication fork. Human WRNIP1 (Werner helicase Interacting Protein 1) associates with various components of the replication machinery...

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Bibliographic Details
Main Authors: Lili Hegedus, Agnes Toth, Gabor M. Harami, Janos Palinkas, Nargis Karatayeva, Eniko Sajben-Nagy, Szabolcs Bene, Sara Afzali Jaktajdinani, Mihaly Kovacs, Szilvia Juhasz, Peter Burkovics
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Subjects:
WRNIP1
G-quadruplex
PIF1
DNA helicase
Genome stability
Replication
Online Access:https://doi.org/10.1038/s41598-024-66425-y

Internet

https://doi.org/10.1038/s41598-024-66425-y

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