Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen

The repurposing of approved drugs is an appealing method to fast-track the development of novel therapies for neglected diseases. Amiodarone and dronedarone, two approved antiarrhythmic agents, have been reported to have potential for the management of Chagas disease patients displaying symptomatic...

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Bibliographic Details
Main Authors: Amanda F. Francisco, Gong Chen, Wen Wang, Melissa L. Sykes, Fanny Escudié, Ivan Scandale, Francisco Olmo, David M. Shackleford, Bilal Zulfiqar, Jadel M. Kratz, Thao Pham, Jessica Saunders, Meiyu Hu, Vicky M. Avery, Susan A. Charman, John M. Kelly, Eric Chatelain
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Tropical Diseases
Subjects:
Trypanosoma cruzi
in vitro
in vivo
bioluminescence imaging
pharmacokinetics
translation
Online Access:https://www.frontiersin.org/articles/10.3389/fitd.2023.1254061/full

Internet

https://www.frontiersin.org/articles/10.3389/fitd.2023.1254061/full

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