Ischemic postconditioning and pinacidil suppress calcium overload in anoxia-reoxygenation cardiomyocytes via down-regulation of the calcium-sensing receptor

Ischemic postconditioning (IPC) and ATP sensitive potassium channel (KATP) agonists (e.g. pinacidil and diazoxide) postconditioning are effective methods to defeat myocardial ischemia-reperfusion (I/R) injury, but their specific mechanisms of reducing I/R injury are not fully understood. We observed...

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Bibliographic Details
Main Authors: Lin Zhang, Song Cao, Shengli Deng, Gang Yao, Tian Yu
Format: Article
Language:English
Published: PeerJ Inc. 2016-11-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/2612.pdf