High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry

Solid tumors account for approximately 90% of all adult human cancers. As such, the development of novel cellular therapies has become of increasing importance to target solid tumor malignancies, such as prostate, lung, breast, bladder, colon, and liver cancers. One such cellular therapy relies on t...

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Bibliographic Details
Main Authors: David Zurowski, Samir Patel, Daniel Hui, Mignane Ka, Charles Hernandez, Andrea C. Love, Bo Lin, Andrea Moore, Leo Li-Ying Chan
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:SLAS Discovery
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555223000138