Dual Inhibition of CDK4/6 and PI3K/AKT/mTOR Signaling Impairs Energy Metabolism in MPM Cancer Cells

Dual Inhibition of CDK4/6 and PI3K/AKT/mTOR Signaling Impairs Energy Metabolism in MPM Cancer Cells

<b>Background</b>: Malignant pleural mesothelioma (MPM) is an aggressive malignancy associated to asbestos exposure. One of the most frequent genetic alteration in MPM patients is <i>CDKN2A/ARF</i> loss, leading to aberrant activation of the Rb pathway. In MPM cells, we previ...

Full description

Bibliographic Details
Main Authors: Mara Bonelli, Rita Terenziani, Silvia Zoppi, Claudia Fumarola, Silvia La Monica, Daniele Cretella, Roberta Alfieri, Andrea Cavazzoni, Graziana Digiacomo, Maricla Galetti, Pier Giorgio Petronini
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
malignant pleural mesothelioma
CDK4/6 inhibition
Palbociclib
PI3K/mTOR inhibitors
metabolism
Online Access:https://www.mdpi.com/1422-0067/21/14/5165

Internet

https://www.mdpi.com/1422-0067/21/14/5165

Similar Items