Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance

Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance

Prolactin-releasing peptide (PrRP) is an anorexigenic neuropeptide that has potential for the treatment of obesity and its complications. Recently, we designed a palmitoylated PrRP31 analog (palm<sup>11</sup>-PrRP31) that is more stable than the natural peptide and able to act centrally...

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Bibliographic Details
Main Authors: Lucia Mráziková, Silvie Hojná, Petra Vaculová, Štěpán Strnad, Vladimír Vrkoslav, Helena Pelantová, Marek Kuzma, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Nutrients
Subjects:
diet-induced obesity
Wistar Kyoto rats
glucose intolerance
prolactin-releasing peptide
liraglutide
lipid metabolism
Online Access:https://www.mdpi.com/2072-6643/15/2/280

Internet

https://www.mdpi.com/2072-6643/15/2/280

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