Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

Antigen recognition through the T cell receptor (TCR) αβ heterodimer is one of the primary determinants of the adaptive immune response. Vaccines activate naïve T cells with high specificity to expand and differentiate into memory T cells. However, antigen-specific memory CD4 T cells exist in unexpo...

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Bibliographic Details
Main Authors: George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
CD4 T cell
T cell receptor
TCR repertoire
vaccination
Online Access:https://elifesciences.org/articles/68388

Internet

https://elifesciences.org/articles/68388

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