Development in the Synthesis, Topoisomerase I inhibitor and Cytototoxic Properties of Indenoisoquinoline and Its Analogs: Review

Development in the Synthesis, Topoisomerase I inhibitor and Cytototoxic Properties of Indenoisoquinoline and Its Analogs: Review

Indenoisoquinolinediones are a class of non-camptothecin topoisomerase I poisons that display marked cytotoxic and potent antitumor properties. Currently three indenoisoquinoline derivatives LMP400 (indotecan, NSC724998), LMP776 (indimitecan, NSC725776) and LMP744 (MJ-III-65, NSC706744) have been po...

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Bibliographic Details
Main Authors: Digafie Zeleke, Ayana Melaku Yadessa
Format: Article
Language:English
Published: Adama Science and Technology University 2021-01-01
Series:Ethiopian Journal of Science and Sustainable Development
Subjects:
indenoisoquinolinediones
cytotoxic
antitumor
Online Access:https://ejssd.astu.edu.et/index.php/EJSSD/article/view/314/78

Internet

https://ejssd.astu.edu.et/index.php/EJSSD/article/view/314/78

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