Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice

Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice

Bone cancer pain (BCP) is common in patients with advanced cancers when the tumors are metastasized to bone. The limited understanding of the complex pathogenesis of BCP leads to the poor effectiveness of clinical treatment. Previous studies have shown that astrocyte-specific connexin (Cx) 43, a for...

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Bibliographic Details
Main Authors: Hui Yang, Hui Yan, Xin Li, Jing Liu, Shousong Cao, Baisheng Huang, Dong Huang, Lixiang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
bone cancer pain
spinal dorsal horn
astrocyte
connexin 43
NR2B
phosphorylation
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00129/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00129/full

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