Total synthesis and antimicrobial evaluation of (+)-hygrophorone B12 and its analogues

Abstract This paper describes the synthesis and evaluation of lead compounds with a new chemical skeleton that is not found in conventional antimicrobial agents. The biologically attractive cyclopentenoid (+)-hygrophorone B12, isolated from the fruiting bodies of Hygrophorus abieticola, and its anal...

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Bibliographic Details
Main Authors: Takaaki Kamishima, Masato Suzuki, Koichi Narita, Yoshitaka Koseki, Toshiyuki Nonaka, Hirotaka Nakatsuji, Hideo Hattori, Hitoshi Kasai
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-11608-8