OLFML2A Downregulation Inhibits Glioma Proliferation Through Suppression of Wnt/β-Catenin Signaling

OLFML2A Downregulation Inhibits Glioma Proliferation Through Suppression of Wnt/β-Catenin Signaling

Glioma is a highly heterogeneous and lethal tumor with an extremely poor prognosis. Through analysis of TCGA data, we identified that OLFML2A is a key promotor of gliomagenesis. However, the molecular function of OLFML2A and its underlying mechanism of action in glioma remain unclear. In this study,...

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Bibliographic Details
Main Authors: Shize Ma, Lei Duan, Huateng Dong, Xiaodong Ma, Xinyu Guo, Jianli Liu, Guoqiang Li, Yue Yu, Yanlong Xu, Guoqiang Yuan, Xingkun Zhao, Guopeng Tian, Shijia Zhai, Yawen Pan, Yinian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
olfactomedin-like 2A (OLFML2A)
glioma
amyloid precursor protein (APP)
proliferation
apoptosis
Wnt/β-catenin signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.717917/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.717917/full

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