Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure–Activity Relationships

Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure–Activity Relationships

Methylglyoxal-induced oxidative stress and cytotoxicity are the main factors causing neuronal death-related, diabetically induced memory impairment. Antioxidant and anti-apoptotic therapy are potential intervention strategies. In this study, 25 flavonoids with different substructures were assayed fo...

Full description

Bibliographic Details
Main Authors: Danyang Zhang, Xia Li, Xiaoshi He, Yan Xing, Bo Jiang, Zhilong Xiu, Yongming Bao, Yuesheng Dong
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
flavonoids
methylglyoxal
PC-12 cells
structure–activity relationship
oxidative stress
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/22/7804

Internet

https://www.mdpi.com/1420-3049/27/22/7804

Similar Items