SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage

SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage

Mounting evidence has suggested that modulating microglia polarization from pro-inflammatory M1 phenotype to anti-inflammatory M2 state might be a potential therapeutic approach in the treatment of subarachnoid hemorrhage (SAH) injury. Our previous study has indicated that sirtuin 1 (SIRT1) could am...

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Bibliographic Details
Main Authors: Da-Yong Xia, Jin-Long Yuan, Xiao-Chun Jiang, Min Qi, Nian-Sheng Lai, Ling-Yun Wu, Xiang-Sheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
microglia polarization
early brain injury
subarachnoid hemorrhage
sirtuin 1
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.770744/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.770744/full

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