Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1

Loss of Paip1 causes translation reduction and induces apoptotic cell death through ISR activation and Xrp1

Abstract Regulation of protein translation initiation is tightly associated with cell growth and survival. Here, we identify Paip1, the Drosophila homolog of the translation initiation factor PAIP1, and analyze its role during development. Through genetic analysis, we find that loss of Paip1 causes...

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Bibliographic Details
Main Authors: Maoguang Xue, Fei Cong, Wanling Zheng, Ruoqing Xu, Xiaoyu Liu, Hongcun Bao, Ying Ying Sung, Yongmei Xi, Feng He, Jun Ma, Xiaohang Yang, Wanzhong Ge
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01587-8

Internet

https://doi.org/10.1038/s41420-023-01587-8

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