EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.

Bibliographic Details
Main Authors: Julian C. Lui, Presley Garrison, Quang Nguyen, Michal Ad, Chithra Keembiyehetty, Weiping Chen, Youn Hee Jee, Ellie Landman, Ola Nilsson, Kevin M. Barnes, Jeffrey Baron
Format: Article
Language:English
Published: Nature Portfolio 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13685

Internet

https://doi.org/10.1038/ncomms13685

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