Synthesis, biological evaluation and molecular docking of pyrimidine and quinazoline derivatives of 1,5-benzodiazepine as potential anticancer agents

Synthesis, biological evaluation and molecular docking of pyrimidine and quinazoline derivatives of 1,5-benzodiazepine as potential anticancer agents

A new series of Pyrimidine (A, D and F) and quinazoline (B, C and E) analogues of 1,5-benzodiazepines were prepared via its nitrile-derived amidoximes in and nitrilium ions, respectively using one pot Domino reaction with DMAD in presence of DABCO catalyst and benzanilide in presence of Tf2O and 2-c...

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Bibliographic Details
Main Authors: Apoorva Misra, Dharma Kishore, Ved Prakash Verma, Sunil Dubey, Subhash Chander, Neha Gupta, Sameer Bhagyawant, Jaya Dwivedi, Zeid A. Alothman, Saikh Mohammad Wabaidur, Swapnil Sharma
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Journal of King Saud University: Science
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364719318579

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http://www.sciencedirect.com/science/article/pii/S1018364719318579

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