The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction

The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction

The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction.

Bibliographic Details
Main Authors: Divya Purushothaman, Laura F. Bianchi, Dmitry Penkov, Alessandro Poli, Qingsen Li, Jelena Vermezovic, Francesca M. Pramotton, Ramveer Choudhary, Fabrizio A. Pennacchio, Elena Sommariva, Marco Foiani, Nils Gauthier, Paolo Maiuri, Francesco Blasi
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03406-9

Internet

https://doi.org/10.1038/s42003-022-03406-9

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