The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction
The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03406-9 |
| _version_ | 1818206852191617024 |
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| author | Divya Purushothaman Laura F. Bianchi Dmitry Penkov Alessandro Poli Qingsen Li Jelena Vermezovic Francesca M. Pramotton Ramveer Choudhary Fabrizio A. Pennacchio Elena Sommariva Marco Foiani Nils Gauthier Paolo Maiuri Francesco Blasi |
| author_facet | Divya Purushothaman Laura F. Bianchi Dmitry Penkov Alessandro Poli Qingsen Li Jelena Vermezovic Francesca M. Pramotton Ramveer Choudhary Fabrizio A. Pennacchio Elena Sommariva Marco Foiani Nils Gauthier Paolo Maiuri Francesco Blasi |
| author_sort | Divya Purushothaman |
| collection | DOAJ |
| description | The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction. |
| first_indexed | 2024-12-12T04:19:36Z |
| format | Article |
| id | doaj.art-efb52baa31d14c348620b90920ea3ae6 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-12T04:19:36Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-efb52baa31d14c348620b90920ea3ae62022-12-22T00:38:21ZengNature PortfolioCommunications Biology2399-36422022-05-015111410.1038/s42003-022-03406-9The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransductionDivya Purushothaman0Laura F. Bianchi1Dmitry Penkov2Alessandro Poli3Qingsen Li4Jelena Vermezovic5Francesca M. Pramotton6Ramveer Choudhary7Fabrizio A. Pennacchio8Elena Sommariva9Marco Foiani10Nils Gauthier11Paolo Maiuri12Francesco Blasi13IFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)EMPA-Materials Science and TechnologyIFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico MonzinoIFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)IFOM (Foundation FIRC Institute of Molecular Oncology)The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction.https://doi.org/10.1038/s42003-022-03406-9 |
| spellingShingle | Divya Purushothaman Laura F. Bianchi Dmitry Penkov Alessandro Poli Qingsen Li Jelena Vermezovic Francesca M. Pramotton Ramveer Choudhary Fabrizio A. Pennacchio Elena Sommariva Marco Foiani Nils Gauthier Paolo Maiuri Francesco Blasi The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction Communications Biology |
| title | The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction |
| title_full | The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction |
| title_fullStr | The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction |
| title_full_unstemmed | The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction |
| title_short | The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction |
| title_sort | transcription factor prep1 pknox1 regulates nuclear stiffness the expression of linc complex proteins and mechanotransduction |
| url | https://doi.org/10.1038/s42003-022-03406-9 |
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