The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex.

The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex.

Subversion of host immune surveillance is a crucial step in viral pathogenesis. Epstein-Barr virus (EBV) encodes two immune evasion gene products, BCRF1 (viral IL-10) and BPLF1 (deubiquitinase/deneddylase); both proteins suppress antiviral immune responses during primary infection. The BCRF1 and BPL...

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Bibliographic Details
Main Authors: Jessica McKenzie, Francesc Lopez-Giraldez, Henri-Jacques Delecluse, Ann Walsh, Ayman El-Guindy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006008

Internet

https://doi.org/10.1371/journal.ppat.1006008

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