Improved estimation of functional enrichment in SNP heritability using feasible generalized least squares

Improved estimation of functional enrichment in SNP heritability using feasible generalized least squares

Summary: Functional enrichment results typically implicate tissue or cell-type-specific biological pathways in disease pathogenesis and as therapeutic targets. We propose generalized linkage disequilibrium score regression (g-LDSC) that requires only genome-wide association studies (GWASs) summary-l...

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Bibliographic Details
Main Authors: Zewei Xiong, Thuan-Quoc Thach, Yan Dora Zhang, Pak Chung Sham
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:HGG Advances
Subjects:
generalized LD score regression
partition heritability
functional enrichment
GWAS summary statistics
complex human traits
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247724000113

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http://www.sciencedirect.com/science/article/pii/S2666247724000113

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