TGFβ selects for pro‐stemness over pro‐invasive phenotypes during cancer cell epithelial–mesenchymal transition

TGFβ selects for pro‐stemness over pro‐invasive phenotypes during cancer cell epithelial–mesenchymal transition

Transforming growth factor β (TGFβ) induces epithelial–mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal–epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic colonization. Whether TGFβ promotes stemness and invasiveness sim...

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Bibliographic Details
Main Authors: Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl‐Henrik Heldin, Aristidis Moustakas
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Molecular Oncology
Subjects:
cancer stem cell
E‐cadherin
epithelial‐mesenchymal transition
invasion
metastasis
transforming growth factor β
Online Access:https://doi.org/10.1002/1878-0261.13215

Internet

https://doi.org/10.1002/1878-0261.13215

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