Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients

Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients

Vincristine (VCR) is an important component of curative chemotherapy for many childhood cancers. Its main side effect is VCR-induced peripheral neuropathy (VIPN), a dose limiting toxicity. Some children are more susceptible to VIPN, which is at least partially dependent on genetic factors and pharma...

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Bibliographic Details
Main Authors: Mirjam E. van de Velde, Aniek Uittenboogaard, Wenjian Yang, Erik Bonten, Cheng Cheng, Deqing Pei, Marleen H. van den Berg, Inge M. van der Sluis, Cor van den Bos, Floor C. H. Abbink, Marry M. van den Heuvel-Eibrink, Heidi Segers, Christophe Chantrain, Jutte van der Werff ten Bosch, Leen Willems, William E. Evans, Gertjan J. L. Kaspers
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
neurotoxicity
children
cancer
vincristine
toxicity
DNA
Online Access:https://www.mdpi.com/2072-6694/14/14/3510

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https://www.mdpi.com/2072-6694/14/14/3510

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