Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes

Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes

The search for peripheral markers of neurodegenerative diseases aims at identifying molecules that could help in monitoring the effects of future therapeutics in easily accessible cells. Here we focused on the involvement of the endocannabinoid system in Huntington's disease (HD). We assayed pe...

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Bibliographic Details
Main Authors: Natalia Battista, Monica Bari, Alessia Tarditi, Caterina Mariotti, Anne-Catherine Bachoud-Lévi, Chiara Zuccato, Alessandro Finazzi-Agrò, Silvia Genitrini, Marc Peschanski, Stefano Di Donato, Elena Cattaneo, Mauro Maccarrone
Format: Article
Language:English
Published: Elsevier 2007-07-01
Series:Neurobiology of Disease
Subjects:
Endocannabinoid
Enzyme inhibition
FAAH
Huntington's disease
Lymphocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001039

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http://www.sciencedirect.com/science/article/pii/S0969996107001039

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