Folding and Binding Mechanisms of the SH2 Domain from Crkl

Folding and Binding Mechanisms of the SH2 Domain from Crkl

SH2 domains are structural modules specialized in the recognition and binding of target sequences containing a phosphorylated tyrosine residue. They are mostly incorporated in the 3D structure of scaffolding proteins that represent fundamental regulators of several signaling pathways. Among those, C...

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Bibliographic Details
Main Authors: Caterina Nardella, Angelo Toto, Daniele Santorelli, Livia Pagano, Awa Diop, Valeria Pennacchietti, Paola Pietrangeli, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomolecules
Subjects:
kinetics
fluorescence
site-directed mutagenesis
protein–protein interactions
SH2 domains
Crkl
Online Access:https://www.mdpi.com/2218-273X/12/8/1014

Internet

https://www.mdpi.com/2218-273X/12/8/1014

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