In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [<sup>125</sup>I]Iodo-ASEM and [<sup>18</sup>F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors

In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [<sup>125</sup>I]Iodo-ASEM and [<sup>18</sup>F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors

The &#945;7 nicotinic acetylcholine receptor (&#945;7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in neurologic and psychiatric diseases, such as schizophrenia and Alzheimer&#8217;s disease, which makes it a relevant drug t...

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Bibliographic Details
Main Authors: Cornelius K. Donat, Henrik H. Hansen, Hanne D. Hansen, Ronnie C. Mease, Andrew G. Horti, Martin G. Pomper, Elina T. L’Estrade, Matthias M. Herth, Dan Peters, Gitte M. Knudsen, Jens D. Mikkelsen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
alpha 7
nicotinic acetylcholine receptors
pet
nachr
autoradiography
Online Access:https://www.mdpi.com/1420-3049/25/6/1425

Internet

https://www.mdpi.com/1420-3049/25/6/1425

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