Multiple molecular pathways in melanomagenesis: characterization of therapeutic targets

Multiple molecular pathways in melanomagenesis: characterization of therapeutic targets

Molecular mechanisms involved in pathogenesis of malignant melanoma have been widely studied and novel therapeutic treatments developed in recent past years. Molecular targets for therapy have mostly been recognized in the RAS-RAF-MEK-ERK and PI3K-AKT signaling pathways; small-molecule inhibitors we...

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Bibliographic Details
Main Authors: Giuseppe ePalmieri, MariaNeve eOmbra, Maria eColombino, Milena eCasula, MariaCristina eSini, Antonella eManca, Panagiotis ePaliogiannis, Paolo Antonio eAscierto, Antonio eCossu
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Oncology
Subjects:
signal transduction cascades
Molecular melanoma classification
Melanoma pathogenesis
Targeted therapy resistance
Alternative therapeutic targets
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00183/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00183/full

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