Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis.

Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis.

BACKGROUND:Tissue-infiltrating multinucleated giant cells (MNGs) within geographic necrosis are pathologic hallmarks of granulomatosis with polyangiitis (GPA). However, the origin, phenotype, and function of these cells in GPA remain undefined. METHODOLOGY/PRINCIPAL FINDINGS:MNG phenotype in GPA lun...

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Bibliographic Details
Main Authors: Jin Kyun Park, Frederic Askin, Jon T Giles, Marc K Halushka, Antony Rosen, Stuart M Levine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3414441?pdf=render

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http://europepmc.org/articles/PMC3414441?pdf=render

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