Modification Strategy of D-leucine Residue Addition on a Novel Peptide from <i>Odorrana schmackeri</i>, with Enhanced Bioactivity and In Vivo Efficacy

Modification Strategy of D-leucine Residue Addition on a Novel Peptide from <i>Odorrana schmackeri</i>, with Enhanced Bioactivity and In Vivo Efficacy

Brevinins are a well-characterised, frog-skin-derived, antimicrobial peptide (AMP) family, but their applications are limited by high cytotoxicity. In this study, a wild-type des-Leu2 brevinin peptide, named brevinin-1OS (B1OS), was identified from <i>Odorrana schmackeri</i>. To explore...

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Bibliographic Details
Main Authors: Aifang Yao, Yingxue Ma, Xiaoling Chen, Mei Zhou, Xinping Xi, Chengbang Ma, Shen Ren, Tianbao Chen, Chris Shaw, Lei Wang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Toxins
Subjects:
brevinin
antimicrobial peptide (AMP)
D-leucine peptide
cytotoxicity
dual antibacterial and anticancer activities
Online Access:https://www.mdpi.com/2072-6651/13/9/611

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https://www.mdpi.com/2072-6651/13/9/611

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