ALKBH5 promotes PD-L1-mediated immune escape through m6A modification of ZDHHC3 in glioma

Abstract N6-methylation of adenosine (m6A) is one of the most frequent chemical modifications in eukaryotic RNAs and plays a vital role in tumorigenesis and progression. Recently, emerging studies have shown that m6A modification by ALKBH5 was associated with immunotherapy response in various types...

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Bibliographic Details
Main Authors: Wenhui Tang, Ningbo Xu, Jian Zhou, Zhenyan He, Cameron Lenahan, Chenyang Wang, Huangyi Ji, Boyang Liu, Yujiao Zou, Huijun Zeng, Hongbo Guo
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01286-w