CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene

CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene

Mutation in the Gjb1 gene, coding for a connexin (Cx32), is associated with an inherited peripheral neuropathic disorder (X-linked Charcot-Marie-Tooth, CMTX). Our previous work reported that transgenic animals expressing a human Gjb1 transgene present polyploidy and abnormal over-duplication of the...

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Bibliographic Details
Main Authors: Saleh eMones, Benoit eBordignon, Franck ePeiretti, jean françois eLandrier, Burkhardt eGess, Jean Jacques eBourguignon, Frédéric eBihel, Michel eFontes
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Neuroscience
Subjects:
Genomic Instability
CaMKII
peripheral neuropathy
CMTX
therapeutical targets
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00151/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00151/full

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