Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis
Abstract Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical inflammatory pathway. The non-canonical inflamm...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-03-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13578-019-0292-0 |
| _version_ | 1818514310972833792 |
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| author | Xiaoli Huang Yang Feng Guanqing Xiong Shona Whyte Jing Duan Yucen Yang Kaiyu Wang Shiyong Yang Yi Geng Yangping Ou Defang Chen |
| author_facet | Xiaoli Huang Yang Feng Guanqing Xiong Shona Whyte Jing Duan Yucen Yang Kaiyu Wang Shiyong Yang Yi Geng Yangping Ou Defang Chen |
| author_sort | Xiaoli Huang |
| collection | DOAJ |
| description | Abstract Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical inflammatory pathway. The non-canonical inflammatory pathway-induced pyroptosis is a unique immune response in response to gram-negative (G−) bacteria. It is induced by lipopolysaccharide (LPS) on the surface of G− bacteria. This activates caspase-11 which, in turn, activates a series of downstream proteins eventually forming protein pores on the cell membrane and inducing cell sacrificial processes. Caspase-11 belongs to the caspase family and is an homologous protein of caspase-1. It has the ability to specifically hydrolyze proteins, but it is still unclear how it regulates cell death caused by non-canonical inflammatory pathways. The present study describes a pathway that enables LPS to directly enter the cell and activate caspase-11, and the key role caspase-11 plays in the activation of pyroptosis and inflammation. |
| first_indexed | 2024-12-11T00:13:58Z |
| format | Article |
| id | doaj.art-efcf745e30ba4c68ad8258cd9d37750a |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-11T00:13:58Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-efcf745e30ba4c68ad8258cd9d37750a2022-12-22T01:28:03ZengBMCCell & Bioscience2045-37012019-03-019111110.1186/s13578-019-0292-0Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosisXiaoli Huang0Yang Feng1Guanqing Xiong2Shona Whyte3Jing Duan4Yucen Yang5Kaiyu Wang6Shiyong Yang7Yi Geng8Yangping Ou9Defang Chen10College of Animal Science & Technology, Sichuan Agricultural UniversityCollege of Animal Science & Technology, Sichuan Agricultural UniversityCollege of Animal Science & Technology, Sichuan Agricultural UniversityAtlantic Veterinary College, University of Prince Edward IslandCollege of Animal Science & Technology, Sichuan Agricultural UniversityCollege of Animal Science & Technology, Sichuan Agricultural UniversityCollege of Veterinary Medicine, Sichuan Agricultural UniversityCollege of Animal Science & Technology, Sichuan Agricultural UniversityCollege of Veterinary Medicine, Sichuan Agricultural UniversityCollege of Veterinary Medicine, Sichuan Agricultural UniversityCollege of Animal Science & Technology, Sichuan Agricultural UniversityAbstract Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical inflammatory pathway. The non-canonical inflammatory pathway-induced pyroptosis is a unique immune response in response to gram-negative (G−) bacteria. It is induced by lipopolysaccharide (LPS) on the surface of G− bacteria. This activates caspase-11 which, in turn, activates a series of downstream proteins eventually forming protein pores on the cell membrane and inducing cell sacrificial processes. Caspase-11 belongs to the caspase family and is an homologous protein of caspase-1. It has the ability to specifically hydrolyze proteins, but it is still unclear how it regulates cell death caused by non-canonical inflammatory pathways. The present study describes a pathway that enables LPS to directly enter the cell and activate caspase-11, and the key role caspase-11 plays in the activation of pyroptosis and inflammation.http://link.springer.com/article/10.1186/s13578-019-0292-0PyroptosisNon-canonical inflammatory pathwayCaspase-1Caspase-11 |
| spellingShingle | Xiaoli Huang Yang Feng Guanqing Xiong Shona Whyte Jing Duan Yucen Yang Kaiyu Wang Shiyong Yang Yi Geng Yangping Ou Defang Chen Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis Cell & Bioscience Pyroptosis Non-canonical inflammatory pathway Caspase-1 Caspase-11 |
| title | Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis |
| title_full | Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis |
| title_fullStr | Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis |
| title_full_unstemmed | Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis |
| title_short | Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis |
| title_sort | caspase 11 a specific sensor for intracellular lipopolysaccharide recognition mediates the non canonical inflammatory pathway of pyroptosis |
| topic | Pyroptosis Non-canonical inflammatory pathway Caspase-1 Caspase-11 |
| url | http://link.springer.com/article/10.1186/s13578-019-0292-0 |
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