HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis

HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis

Leflunomide is used for the treatment of rheumatoid arthritis. Here, the authors show that effectiveness is limited in patients with higher levels of serum c-reactive protein (CRP). Using animal models, they show that higher CRP induces HIF1a expression, which in turn interferes with Leflunomide sig...

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Bibliographic Details
Main Authors: Chao Liang, Jie Li, Cheng Lu, Duoli Xie, Jin Liu, Chuanxin Zhong, Xiaohao Wu, Rongchen Dai, Huarui Zhang, Daogang Guan, Baosheng Guo, Bing He, Fangfei Li, Xiaojuan He, Wandong Zhang, Bao-Ting Zhang, Ge Zhang, Aiping Lu
Format: Article
Language:English
Published: Nature Portfolio 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12163-z

Internet

https://doi.org/10.1038/s41467-019-12163-z

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