Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1

Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1

ABSTRACT Nonstructural protein 1 (Nsp1) of severe acute respiratory syndrome coronaviruses (SARS-CoVs) is an important pathogenic factor that inhibits host protein translation by means of its C terminus. However, its N-terminal function remains elusive. Here, we determined the crystal structure of t...

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Bibliographic Details
Main Authors: Kaitao Zhao, Zunhui Ke, Hongbing Hu, Yahui Liu, Aixin Li, Rong Hua, Fangteng Guo, Junfeng Xiao, Yu Zhang, Ling Duan, Xin-Fu Yan, Yong-Gui Gao, Bing Liu, Yuchen Xia, Yan Li
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
N terminus
Nsp1
SARS-CoV-2
crystal structure
protein translation
ribosome
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00169-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00169-21

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