GDF11 Alleviates Pathological Myocardial Remodeling in Diabetic Cardiomyopathy Through SIRT1-Dependent Regulation of Oxidative Stress and Apoptosis

GDF11 Alleviates Pathological Myocardial Remodeling in Diabetic Cardiomyopathy Through SIRT1-Dependent Regulation of Oxidative Stress and Apoptosis

Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β superfamily that alleviates cardiac hypertrophy, myocardial infarction, and vascular injury by regulating oxidative stress, inflammation, and cell survival. However, the roles and underlying mechanisms of GDF11...

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Bibliographic Details
Main Authors: Han-Zhao Zhu, Li-Yun Zhang, Meng-En Zhai, Lin Xia, Yu Cao, Lu Xu, Kai-Feng Li, Li-Qing Jiang, Heng Shi, Xiang Li, Ye-Nong Zhou, Wei Ding, Dong-Xu Wang, Er-He Gao, Jin-Cheng Liu, Shi-Qiang Yu, Wei-Xun Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
growth differentiation factor 11
diabetic cardiomyopathy
sirtuin 1
oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.686848/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.686848/full

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