Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha

Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha

The neuronal DNA-/RNA-binding protein Pur-alpha is a transcription regulator and core factor for mRNA localization. Pur-alpha-deficient mice die after birth with pleiotropic neuronal defects. Here, we report the crystal structure of the DNA-/RNA-binding domain of Pur-alpha in complex with ssDNA. It...

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Bibliographic Details
Main Authors: Janine Weber, Han Bao, Christoph Hartlmüller, Zhiqin Wang, Almut Windhager, Robert Janowski, Tobias Madl, Peng Jin, Dierk Niessing
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
DNA-/RNA-protein interaction
DNA unwinding
FXTAS
ALS
5q31.3 microdeletion syndrome
X-ray crystallography
Online Access:https://elifesciences.org/articles/11297

Internet

https://elifesciences.org/articles/11297

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