Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

IntroductionL-Asparaginase (L-Asp) is a key drug in the treatment of acute lymphoblastic leukemia (ALL); however, it is commonly associated with the occurrence of adverse events (AE). Risk factors such as age, sex, nutritional status, and some single nucleotide variants (SNVs) in specific genes coul...

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Main Authors: Jesús Alonso Gándara-Mireles, Ismael Lares-Asseff, Elio Aarón Reyes Espinoza, Verónica Loera Castañeda, Lourdes Patricia Córdova Hurtado, Flor de María Reyes Gutiérrez, Antonio Sandoval-Cabrera, Ignacio Villanueva Fierro, Julio Cesar Grijalva Ávila, Claudia Castro Arreola, Leslie Patrón-Romero, Horacio Almanza Reyes
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Pharmacology
Subjects:
single-nucleotide variants
L-asparaginase
adverse events
leukemia
children
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1423049/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1423049/full

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