Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease

Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease

Abstract Background Molecular characterization of late-onset Alzheimer’s disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway alterations associated with disease. Assessing these postmortem signatures of LOAD in experimental model systems can fur...

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Bibliographic Details
Main Authors: Ravi S. Pandey, Kevin P. Kotredes, Michael Sasner, Gareth R. Howell, Gregory W. Carter
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Genomics
Subjects:
Genetics
Alzheimer’s disease
Mouse models
Genomics
Splicing
Transcriptomics
Online Access:https://doi.org/10.1186/s12864-023-09280-x

Internet

https://doi.org/10.1186/s12864-023-09280-x

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