An overview of PROTACs: a promising drug discovery paradigm

An overview of PROTACs: a promising drug discovery paradigm

Abstract Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic paradigm in recent years. PROTACs are heterobifunctional molecules that degrade target proteins by hijacking the ubiquitin–proteasome system. Currently, about 20–25% of all protein targets are being studi...

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Bibliographic Details
Main Authors: Zi Liu, Mingxing Hu, Yu Yang, Chenghao Du, Haoxuan Zhou, Chengyali Liu, Yuanwei Chen, Lei Fan, Hongqun Ma, Youling Gong, Yongmei Xie
Format: Article
Language:English
Published: Springer 2022-12-01
Series:Molecular Biomedicine
Subjects:
PROTAC
Protein degradation
Ubiquitin–proteasome system
Design and synthesis
Online Access:https://doi.org/10.1186/s43556-022-00112-0

Internet

https://doi.org/10.1186/s43556-022-00112-0

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