Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.

Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.

Cultured cells easily develop resistance to kinesin-5 inhibitors (K5Is) often by overexpressing a related motor protein, kinesin-12/KIF15, or by acquiring mutations in the N-terminal motor domain of kinesin-5/KIF11 itself. We aimed to identify novel mechanisms responsible for resistance to S-trityl...

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Bibliographic Details
Main Authors: Eri Saeki, Shinji Yasuhira, Masahiko Shibazaki, Hiroshi Tada, Minoru Doita, Tomoyuki Masuda, Chihaya Maesawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209296

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https://doi.org/10.1371/journal.pone.0209296

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