Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx.

Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx.

Human Immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) succeed to evade host immune defenses by using their viral auxiliary proteins to antagonize host restriction factors. HIV-2/SIVsmm Vpx is known for degrading SAMHD1, a factor impeding the reverse transcription. More recently, Vpx was also...

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Bibliographic Details
Main Authors: Michaël M Martin, Roy Matkovic, Pauline Larrous, Marina Morel, Angélique Lasserre, Virginie Vauthier, Florence Margottin-Goguet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009609

Internet

https://doi.org/10.1371/journal.ppat.1009609

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