Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer

Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer

Abstract Background Pancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for pancreatic cancer by establishing and characterizing patient-derived organoids (PDOs). Methods PDOs were established from pancreatic tumor surgi...

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Bibliographic Details
Main Authors: Sadanori Watanabe, Akitada Yogo, Tsuguteru Otsubo, Hiroki Umehara, Jun Oishi, Toru Kodo, Toshihiko Masui, Shigeo Takaishi, Hiroshi Seno, Shinji Uemoto, Etsuro Hatano
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
Organoid
Peritoneal dissemination
Xenograft model
Compound screening
Online Access:https://doi.org/10.1186/s12885-022-09619-9

Internet

https://doi.org/10.1186/s12885-022-09619-9

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