Effective Delivery of Hypertrophic miRNA Inhibitor by Cholesterol‐Containing Nanocarriers for Preventing Pressure Overload Induced Cardiac Hypertrophy

Effective Delivery of Hypertrophic miRNA Inhibitor by Cholesterol‐Containing Nanocarriers for Preventing Pressure Overload Induced Cardiac Hypertrophy

Abstract Persistent cardiac hypertrophy causes heart failure and sudden death. Gene therapy is a promising intervention for this disease, but is limited by the lack of effective delivery systems. Herein, it is reported that CHO‐PGEA (cholesterol (CHO)‐terminated ethanolamine‐aminated poly(glycidyl m...

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Bibliographic Details
Main Authors: Ying Zhi, Chen Xu, Dandan Sui, Jie Du, Fu‐Jian Xu, Yulin Li
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Advanced Science
Subjects:
cardiac hypertrophy
cardiomyocyte transfection
gene therapy
miRNA delivery
nanocarriers
Online Access:https://doi.org/10.1002/advs.201900023

Internet

https://doi.org/10.1002/advs.201900023

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