Encapsulation of Human-Bone-Marrow-Derived Mesenchymal Stem Cells in Small Alginate Beads Using One-Step Emulsification by Internal Gelation: In Vitro, and In Vivo Evaluation in Degenerate Intervertebral Disc Model

Encapsulation of Human-Bone-Marrow-Derived Mesenchymal Stem Cells in Small Alginate Beads Using One-Step Emulsification by Internal Gelation: In Vitro, and In Vivo Evaluation in Degenerate Intervertebral Disc Model

Cell microencapsulation in gel beads contributes to many biomedical processes and pharmaceutical applications. Small beads (<300 µm) offer distinct advantages, mainly due to improved mass transfer and mechanical strength. Here, we describe, for the first time, the encapsulation of human-bone-marr...

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Bibliographic Details
Main Authors: Sarit S. Sivan, Iris Bonstein, Yariv N. Marmor, Gadi Pelled, Zulma Gazit, Michal Amit
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
microencapsulation
emulsification
internal gelation
alginate beads
mesenchymal stem cells
mammalian cells
Online Access:https://www.mdpi.com/1999-4923/14/6/1179

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https://www.mdpi.com/1999-4923/14/6/1179

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