Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA

Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA

Abstract Background The respiratory pathogen Streptococcus pneumoniae (the pneumococcus) is a genetically diverse bacterium associated with over 101 immunologically distinct polysaccharide capsules (serotypes). Polysaccharide conjugate vaccines (PCVs) have successfully eliminated multiple targeted s...

Full description

Bibliographic Details
Main Authors: Min Jung Kwun, Alexandru V. Ion, Hsueh-Chien Cheng, Joshua C. D’Aeth, Sam Dougan, Marco R. Oggioni, David A. Goulding, Stephen D. Bentley, Nicholas J. Croucher
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Genome Medicine
Subjects:
Genomic epidemiology
Pneumococcus
Vaccine
Prophage
Transformation
Recombination
Online Access:https://doi.org/10.1186/s13073-022-01147-2

Internet

https://doi.org/10.1186/s13073-022-01147-2

Similar Items