Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

Symptomatic treatment of myasthenia gravis is based on the use of peripherally-acting acetylcholinesterase (AChE) inhibitors that, in some cases, must be discontinued due to the occurrence of a number of side-effects. Thus, new AChE inhibitors are being developed and investigated for their potential...

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Bibliographic Details
Main Authors: Carles Galdeano, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Manuela Bartolini, Belén Pérez, M. Victòria Clos, Israel Silman, Ludovic Jean, Jacques-Philippe Colletier, Pierre-Yves Renard, Diego Muñoz-Torrero
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
acetylcholinesterase inhibitors
butyrylcholinesterase inhibitors
quinolinium compounds
triazoles
structural biology
copper-catalyzed azide-alkyne cycloaddition
click chemistry
Online Access:http://www.mdpi.com/1420-3049/23/3/634

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http://www.mdpi.com/1420-3049/23/3/634

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