Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

In the hippocampus, a widely accepted model posits that the dentate gyrus improves learning and memory by enhancing discrimination between inputs. To test this model, we studied conditional knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop – including nearly al...

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Bibliographic Details
Main Authors: Amir Rattner, Chantelle E Terrillion, Claudia Jou, Tina Kleven, Shun Felix Hu, John Williams, Zhipeng Hou, Manisha Aggarwal, Susumu Mori, Gloria Shin, Loyal A Goff, Menno P Witter, Mikhail Pletnikov, André A Fenton, Jeremy Nathans
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
dentate gyrus
hippocampus
learning
memory
Online Access:https://elifesciences.org/articles/62766

Internet

https://elifesciences.org/articles/62766

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