Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD

Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD

Summary: Metformin prevents progression of non-alcoholic fatty liver disease (NAFLD). However, the potential mechanism is not entirely understood. Ferroptosis, a recently recognized nonapoptotic form of regulated cell death, has been reported to be involved in the pathogenesis of NAFLD. Here, we inv...

Full description

Bibliographic Details
Main Authors: Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan Russell, Dongmei Zhang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Pharmacology
Biological sciences
Biochemistry
Physiology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223026378

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223026378

Similar Items