Interactions in the 2×2×2 factorial randomised clinical STEPCARE trial and the potential effects on conclusions: a protocol for a simulation study

Interactions in the 2×2×2 factorial randomised clinical STEPCARE trial and the potential effects on conclusions: a protocol for a simulation study

Abstract Background Randomised clinical trials with a factorial design may assess the effects of multiple interventions in the same population. Factorial trials are carried out under the assumption that the trial interventions have no interactions on outcomes. Here, we present a protocol for a simul...

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Bibliographic Details
Main Authors: Markus Harboe Olsen, Aksel Karl Georg Jensen, Josef Dankiewicz, Markus B. Skrifvars, Matti Reinikainen, Marjaana Tiainen, Manoj Saxena, Anders Aneman, Christian Gluud, Susann Ullén, Niklas Nielsen, Janus Christian Jakobsen
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Trials
Subjects:
Simulation study
Protocol
Interactions
Factorial design
Randomised clinical trial
Statistical analysis plan
Online Access:https://doi.org/10.1186/s13063-022-06796-7

Internet

https://doi.org/10.1186/s13063-022-06796-7

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