SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway

SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway

Abstract Background Optimal therapeutic strategies for hepatocellular carcinoma (HCC) patients are still challenging due to the high recurrence rate after surgical resection and chemotherapy resistance. Growing evidence shows that genetic and epigenetic alterations are involved in HCC progression an...

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Bibliographic Details
Main Authors: Jie Zhao, Ann Wozniak, Abby Adams, Josiah Cox, Anusha Vittal, Jordan Voss, Brian Bridges, Steven A. Weinman, Zhuan Li
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Histone deacetylase
HCC
TACE resistance
NOXA
Deacetylation
Online Access:http://link.springer.com/article/10.1186/s13046-019-1246-4

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http://link.springer.com/article/10.1186/s13046-019-1246-4

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