A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance

A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance

Malignant melanoma cell-intrinsic PD-1:PD-L1 interaction thrusts tumorigenesis, angiogenesis, and radioresistance via mTOR hyperactivation to aggravate circumjacent aggression. Interdicting melanoma intrinsic growth signals, including the blockade of PD-L1 and mTOR signaling concurrently, cooperativ...

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Bibliographic Details
Main Authors: Wenxi Li, Jie Yan, Hao Tian, Bei Li, Guohao Wang, Wei Sang, Zhan Zhang, Xuanjun Zhang, Yunlu Dai
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-04-01
Series:Bioactive Materials
Subjects:
platinum@polymer-catechol nanobrakers
Melanoma PD-1:PD-L1 interaction blockade
Radio-sensitization effect
Anti-tumorigenesis
Anti-angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22003899

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http://www.sciencedirect.com/science/article/pii/S2452199X22003899

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